In Vitro Immunomodulatory Activity of Fig Fruit Ethanol Extract (Ficus carica Linn) against Phagocytosis Macrophages and Lymphocyte Proliferation

Fig (Ficus carica L.) is a natural product that potentially can improve the immune system because it has flavonoids have potential as immunostimulants. The research aims to determine possibility of fig fruit ethanol extract an immunomodulator. Immunomodulatory activity determined by knowing macrophage phagocytosis and lymphocyte proliferation in vitro levels extract. began with extraction, then sample was tested TLC colorimetry methods. Furthermore, immunomodulatory test measured through proliferation. In test, cells were given samples various concentrations latex beads. number activated macrophages phagocyted calculated. For tests activity, sampled different induced hepatitis B vaccine. Then cell absorbance read Elisa reader at 550nm wavelength. study results found contained flavonoid compounds, total obtained 0.74±0.01 mgEQ/g samples. showed increased compared control. produced stimulation index<2 values, showing no effect on lymphocytes. This indicated could increase but did not affect vitro.